Following the emotionally charged third-season finale, Blindspot returns for its fourth season. Jane (Jaimie Alexander) is being poisoned by ZIP, the very drug used to wipe her memory. Also suffering from the disease, her brother Roman (Luke Mitchell) was searching for a cure and hid caches of data all over the globe. The team will follow a trail of cryptic bread crumbs that leads to all-new crimes and, with any luck, a cure to save Jane. Season Four begins with Weller (Sullivan Stapleton) on the brink of death and Remi having returned from the depths of Jane's mind. Not knowing that Zapata (Audrey Esparza) has joined the villainous HCI Global, Reade (Rob Brown) tries desperately to find her. At the same time, Patterson (Ashley Johnson) hunts to cure Jane with Rich DotCom (new series regular Ennis Esmer). Embracing last season's global scope, Season Four's action-packed missions will take the team all over Europe and South America.